Upsilon General is supporting the growth of an established international medical-device organisation with an expanding clinical research portfolio.
We are currently seeking an experienced Senior Clinical Research Associate / CRA II to join the clinical operations team on a permanent basis, supporting the successful delivery of clinical studies across Argentina and internationally.
This opportunity would suit a clinical research professional with strong monitoring experience who is looking to take greater ownership of their work, collaborate closely with international study teams, and gain broader exposure within a growing medical-device organisation.
POSITION DETAILS
Position:
Senior Clinical Research Associate / CRA II
Location:
Argentina
Contract:
Permanent
Start Date:
January
Experience:
Minimum 2 years of clinical trial monitoring experience
Languages:
Portuguese and English
Travel:
Regular travel within Argentina, with occasional international travel
ABOUT THE OPPORTUNITY
The organisation combines scientific expertise with strong operational delivery and close collaboration across international clinical research teams.
The successful candidate will be responsible for supporting clinical trial sites throughout the study lifecycle, from study start-up through to close-out.
This will include conducting monitoring visits, maintaining strong site relationships, ensuring compliance with study protocols and applicable regulations, and supporting overall study quality.
The role provides an opportunity to work within a growing organisation where clinical research professionals can have meaningful involvement in their projects and broader exposure to the organisation's activities.
KEY REQUIREMENTS
Minimum of 2 years' experience working as a Clinical Research Associate
Minimum of 2 years' clinical trial monitoring experience
Experience conducting independent monitoring visits
Experience with interventional clinical trials
Strong knowledge of ICH-GCP, clinical trial regulations and monitoring practices
Experience across the clinical trial lifecycle, from study start-up through to close-out
Experience conducting Site Selection Visits, Site Initiation Visits, Monitoring Visits and Close-Out Visits




Strong understanding of Source Data Verification (SDV) and Source Data Review (SDR)
Experience working with investigators, study coordinators and clinical trial sites
Strong organisational and time-management skills
Excellent attention to detail and commitment to quality
Strong problem-solving skills and a proactive approach to identifying and resolving site issues
Ability to work independently while contributing effectively to an international study team
Strong written and verbal communication skills
Fluency in Portuguese and English
Willingness and ability to travel regularly within Argentina and occasionally internationally
KEY RESPONSIBILITIES
The successful candidate will be responsible for:
Conducting Site Selection Visits, Site Initiation Visits, Monitoring Visits and Close-Out Visits
Monitoring clinical trial sites in accordance with study protocols, sponsor requirements, ICH-GCP and applicable regulations
Conducting Source Data Verification and Source Data Review to ensure data quality and accuracy
Reviewing informed consent documentation and supporting appropriate patient safety and subject protection
Identifying, documenting and following up on protocol deviations, site issues and study-related risks
Providing support and guidance to investigators and site staff regarding study requirements
Maintaining effective communication with investigators, study coordinators, sponsors and internal study teams
Preparing accurate and high-quality monitoring reports within required timelines
Ensuring essential regulatory and study documentation is complete, accurate and inspection ready
Supporting risk-based monitoring activities and overall study quality oversight
Supporting study start-up, recruitment, study maintenance and close-out activities
Monitoring site performance and following up on outstanding actions




Reviewing CRFs, Investigator Site Files and other essential study documentation
Supporting regulatory submissions and approvals where required
Supporting the resolution of audit findings and implementation of corrective actions
Ensuring adverse events and serious adverse events are appropriately documented and followed up
Supporting the reconciliation and close-out of study materials, documentation and site activities
SYSTEMS AND TECHNICAL EXPERIENCE
Experience with clinical research systems and software would be beneficial, including:
Veeva
Oracle
Medidata RAVE
CTMS
eTMF systems
Microsoft Word
Microsoft Excel
Microsoft PowerPoint
MS Project
The successful candidate should also be comfortable learning and working with clinical research systems and maintaining accurate documentation within required timelines.
ADDITIONAL SKILLS
We are looking for a professional who demonstrates:
Strong interpersonal and relationship-building skills
Excellent communication with clinical research sites and study stakeholders
The ability to manage multiple priorities effectively
Strong problem-solving and decision-making skills
A proactive approach to site management and issue resolution
High attention to detail
A strong understanding of clinical trial quality and compliance requirements
The ability to build and maintain effective relationships with investigators and site teams
The ability to collaborate with colleagues and stakeholders across different countries and cultures
A flexible and adaptable approach to working within a growing clinical research environment
A client-focused mindset and commitment to delivering high-quality work within agreed timelines
WHY CONSIDER THIS OPPORTUNITY?
As a smaller medical-device organisation, this role offers:
Greater visibility and ownership across clinical research activities.
Closer access to senior leadership and key decision-makers.
Direct exposure to product development and the impact of clinical research.
Broader responsibilities and professional exposure across the organisation.
Strong career development opportunities within a growing environment.
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📌 Senior Clinical Research Associate (Buenos Aires)
🏢 Upsilon Global
📍 Buenos Aires