Computational Scientist at axiombio
About the role: We are seeking a talented Computational Scientist to join our innovative team at axiombio, where you will play a pivotal role in establishing the computational and biological framework for our toxicity prediction platform. This position will involve delving into extensive and varied toxicity datasets to uncover biological signals, enhance predictive models, and develop new assays. Your contributions will be vital in the creation of AI systems that elucidate mechanisms and inform drug design processes.
Key facts
Location: San Francisco Integral Headquarters.
Engagement: Full-time.
Compensation: Not specified.
Team: General.
What you'll do
- Spearhead the investigation and analysis of large-scale multimodal toxicity datasets, which encompass imaging, transcriptomics, proteomics, and functional cellular readouts.
- Identify subtle biological markers that can effectively differentiate between safe and toxic compounds across various human systems, including the liver, heart, kidneys, and immune system.
- Convert complex,



high-dimensional experimental data into actionable biological insights, robust features, quality metrics, and datasets that are primed for modeling.
- Examine high-content imaging and transcriptomic data derived from primary human hepatocytes and multicellular hepatic systems, with a focus on phenotypes such as mitochondrial dysfunction and endoplasmic reticulum stress.
- Perform thorough model error analyses to evaluate model performance, pinpoint failures, and ascertain the need for additional data or new assays.
- Collaborate with machine learning experts to refine models that predict human toxicity based on factors such as dose, exposure, chemical structure, and biological response.
- Develop computational techniques for extracting significant signals from imaging, transcriptomic, proteomic, and biochemical assays.
- Design and enhance quality control systems for large-scale, high-throughput biologica

📌 Computational Scientist (Santa Fe)
🏢 axiombio
📍 Santa Fe