Agent Harness Engineer at axiombio.
About the role Axiom is constructing an agentic infrastructure layer designed to supplant animal testing and fundamentally reshape pharmaceutical drug discovery workflows. In this position, you will architect the foundational scaffolding that empowers frontier models to execute complex, long-horizon scientific reasoning across proprietary human biological datasets. The work sits at the intersection of advanced AI systems engineering and computational biology, requiring the translation of wet-lab scientific rigor into reliable, automated software processes. You will be responsible for the reliability and observability of the autonomous loops that drive scientific insight generation. This is a high-agency role where the engineering playbook is being written in real-time alongside the core technology.
Key facts
Location: SF General HQ Engagement: FullTime
What you'll do




- Architect and implement the core infrastructure and tooling necessary to evolve frontier large language models into fully autonomous scientific agents capable of independent hypothesis generation and validation.
- Construct sandboxed, deterministic execution environments that guarantee reproducibility for rigorous evaluation suites and reinforcement learning training runs.
- Develop and maintain high-throughput data pipelines for ingesting, storing, and versioning agent trajectories, runtime context windows, and synthetic training datasets.
- Design comprehensive evaluation frameworks encompassing offline static test suites, automated regression gates, and sophisticated LLM-as-judge pipelines for subjective scientific quality assessment.
- Implement deep observability and introspection tooling to trace every model invocation, tool interaction, and state transition for debugging and auditability.
- Engineer robust memory management, retrieval-augmented generation (RAG) systems, and checkpoint recovery mechanisms to maintain agent coherence over extended, multi-step an

📌 Agent Harness Engineer (Santa Fe)
🏢 axiombio
📍 Santa Fe